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Two charged in connection with Iran drone strike that killed US troops(BPT) - This article was sponsored and developed by Neurocrine Biosciences, Inc. Cerebral palsy (CP) is a neurodevelopmental disorder affecting movement and posture that begins in early childhood development. It is the most common cause of motor disability in children, affecting about one in 345 children in the United States. 1-2 It may happen as a result of lack of oxygen during or around birth, stroke, infection, a problem with metabolism or other problems that cause injury or affect the development of parts of the brain involved in movement control in the first few years of life. 3 CP is a permanent condition, affecting a person for their entire life. People living with CP typically have motor problems, which may include spasticity (abnormal muscle tightness), dyskinesia (uncontrolled movements) or ataxia (poor muscle control), and many people have a mix of these motor disorders. 4 Dyskinesia due to CP (DCP) is one of the most disabling forms of CP and impacts approximately 10% to 20% of people living with CP. 5-6 According to the Cerebral Palsy Foundation (CPF), the combination of irregular and unpredictable movements (chorea) and twisting and repeating movements (dystonia) often disrupt activities and cause significant functional impairment, including the ability to maintain balance, walk or fine motor control. 7 Heather Riordan, M.D., Neurologist and Movement Disorders Specialist, Director of the Phelps Center for Cerebral Palsy at the Kennedy Krieger Institute, discusses the symptoms of chorea and impact on patients in a video shared on the CPF website here . About 30% of people with DCP are affected mostly by these involuntary and irregular movements (chorea), while dystonia is the predominant motor finding in the remaining 70%. 8 However, it is common for both chorea and dystonia movements to be present together. 6 For people living with DCP, these movements can occur in any region of the body, including the arms and legs, torso and face and may vary in severity. They are often triggered or made worse by stimulation or stress. Because dyskinesia can occur at rest and/or when actively using the body, the problems with movement are very burdensome in day-to-day living, with discomfort and pain affecting the quality of life for people and their caregivers. 9 Jen Lyman, mom to a son with DCP, highlights how dyskinesia makes communicating more difficult. "The most difficult thing about dyskinesia is watching my son struggle to do things that he wants to do, but the extra movements get in the way...special things, such as using a touch screen to video chat with his grandmother, are nearly impossible despite his best efforts to use his hands and fingers. Something so simple, yet so special for him should be effortless." DCP has a wide-ranging impact on the individual, including lifelong challenges with movement, a higher risk of other medical issues, a higher rate of mental health challenges and difficulties with communication. 10-12 "Those of us who have the privilege to serve patients with dyskinetic, hyperkinetic or mixed cerebral palsy see the functional impact of this very challenging type of tone every day," said Susan Biffl, M.D., Rehabilitation Medicine Specialist at Rady Children's Hospital-San Diego and Assistant Professor at UC San Diego School of Medicine. "Patients face challenges with self-care, independence, mobility, communication, fine motor skills that affect occupational and recreational activities, swallowing, social interactions and even sleep. As this tone is variable, it is much more challenging to treat than more consistent tone issues, such as spasticity." Treatment Options There are currently no Food and Drug Administration-approved treatments for DCP. Dystonia and chorea are often managed separately as they respond differently to various treatments, which can make treatment challenging. 3 Most drugs being investigated for DCP have focused on dystonia, and more research is needed to determine potential treatments for chorea. New treatment options are needed to help manage these movement disorders and improve daily function and quality of life for those affected. "After 20 years of caring for individuals with cerebral palsy, I continue to find those with dyskinetic cerebral palsy among the most challenging to treat, largely due to the limited effectiveness of available pharmacologic options," said Joyce Oleszek, M.D., Professor, Department of Physical Medicine and Rehabilitation, University of Colorado School of Medicine. "There is an urgent need for more robust evidence to support pharmacologic treatments for this condition, given its profound impact on function, comfort and quality of life." Ongoing Research Clinical studies are important in the development of treatment options, allowing researchers to evaluate the safety and effectiveness of new medicines. The data from clinical studies are used to determine if an investigational treatment can be approved for use to treat certain disorders. There are ongoing clinical studies evaluating potential treatments for DCP, including one for chorea. Neurocrine Biosciences is conducting the KINECT ® -DCP clinical study, a Phase 3, randomized, double-blind placebo-controlled study investigating the study drug, valbenazine, for the treatment of DCP. The clinical study is currently enrolling children, adolescents and adults six to 70 years of age who have been diagnosed with DCP. "The Cerebral Palsy Foundation is excited to partner with Neurocrine Biosciences on this study," said Rachel Byrne, Executive Director of the Cerebral Palsy Foundation. "We are proud to support strong research that can potentially bring meaningful change to the lives of those living with cerebral palsy." If you or someone you know may be eligible for this research study, please visit the study website for additional information here: FindADCPStudy.com . REFERENCES © 2024 Neurocrine Biosciences, Inc. All Rights Reserved. CAP-NBI-US-0115 12/2024 NBI-98854-DCP3018_11DecMatRelease_v1.0_25November2024what is t spin 。

House approves $895B defense bill with military pay raise, ban on transgender care for minors"We are not doing AI for the sake of it. We're doing it with purpose." — James Rail, QUT Hear the entire iTnews podcast with QUT's James Rail For many people, while university may be a thrilling experience, it may also be daunting and confusing — even frightening. Thrust into a world of adults, people who were high schoolers just a scant couple of months earlier quickly learn the truth of the adage to 'sink or swim'. And while Australian universities continue to lift student support services, vulnerable cohorts such as First Nations, overseas students or those from Non-English-language-speaking backgrounds, and people living with other challenges need focused support at point of contact. The desire to meet the evolving needs of students was one of the reasons that Queensland University of Technology (QUT) embarked on 'Digital Connections', its multi-year data + AI program to transform how the institution can connect with and support students, staff and alumni. It created a 360-degree view of students from their initial consideration of QUT as a place to study, through their uni years and onwards as successful alumni. Led by James Rail, QUT's digital transformation program leader, Digital Connections has utilised Salesforce to unify previously siloed frontline...

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CARBONDALE, Ill. (AP) — Southern Illinois quarterback Michael Lindauer's coming-out party also was a dazzling farewell. Read this article for free: Already have an account? To continue reading, please subscribe: * CARBONDALE, Ill. (AP) — Southern Illinois quarterback Michael Lindauer's coming-out party also was a dazzling farewell. Read unlimited articles for free today: Already have an account? CARBONDALE, Ill. (AP) — Southern Illinois quarterback Michael Lindauer’s coming-out party also was a dazzling farewell. The senior graduate assistant, pressed into duty as a player again when injuries left the Salukis in need of a quarterback, made his first career start — on Senior Day, no less — and threw for a school-record seven touchdowns in a 62-0 victory over Murray State on Saturday. “This was incredible,” Lindauer said. “The guys around me — thank the guys. The receivers were making plays, the O-line’s blocking. When you get on a roll like that, stuff just starts happening.” The fifth-year senior, a transfer from Cincinnati, completed 20 of 33 passes for 283 yards. Keontez Lewis caught scoring passes of 4 and 64 yards. Bradley Clark had TDs of 35 and 23 yards. Nah’shawn Hezekiah had touchdowns of 19 and 35 yards on his two catches. And Jay Jones caught one pass for 1 yard — also a touchdown. Before the game, Lindauer had attempted 27 career passes. “Now, he’s in the record book,” Salukis coach Nick Hill said. “It will be a hard record to beat, seven TDs in one game. ... What he’s done ... just being so selfless and coming back and being a player. The team needed it. ... It’s a testament that if you stay committed, do the right things, have a great attitude, you’re going to get rewarded at some point, and he was rewarded in a big way today.” Southern Illinois finished the season 4-8 overall and 2-5 in the Missouri Valley Conference, but “to go out like that, that’s a good way to go out,” Hill said. Lindauer was named the MVC offensive player of the week for his performance in his first and last career start. He plans to return in the spring, again as a graduate assistant coach, but this time with a resume to lean on. ___ AP college football: https://apnews.com/hub/ap-top-25-college-football-poll and https://apnews.com/hub/college-football Advertisement

Arteta wanted his team to prove their European credentials following some underwhelming displays away from home, and the Gunners manager got exactly what he asked for. Goals from Gabriel Martinelli, Kai Havertz, Gabriel Magalhaes, Bukayo Saka and Leandro Trossard got their continental campaign back on track in style following the 1-0 defeat at Inter Milan last time out. A memorable victory also ended Sporting’s unbeaten start to the season, a streak of 17 wins and one draw, the vast majority of which prompted Manchester United to prise away head coach Ruben Amorim. The Gunners had failed to win or score in their two away games in the competition so far this season, but they made a blistering start in the Portuguese capital and took the lead after only seven minutes. Declan Rice fed overlapping full-back Jurrien Timber, who curled a low cross in behind the home defence for Martinelli to finish at the far post. Arsenal doubled their lead in the 20th minute thanks to a glorious ball over the top from Thomas Partey. Saka escaped the clutches of his marker Maximiliano Araujo to beat the offside trap and poke the ball past advancing goalkeeper Franco Israel for Havertz to tap home. It was a scintillating first-half display which completely overshadowed the presence of Viktor Gyokeres in Sporting’s attack. The prolific Sweden striker, formerly of Coventry, has been turning the heads of Europe’s top clubs with his 24 goals in 17 games this season – including a hat-trick against Manchester City earlier this month. But the only time he got a sniff of a run at goal after an optimistic long ball, he was marshalled out of harm’s way by Gabriel. David Raya was forced into one save, tipping a fierce Geovany Quenda drive over the crossbar. But Arsenal added a third on the stroke of half-time, Gabriel charging in to head Rice’s corner into the back of the net. To rub salt in the wound, the Brazilian defender mimicked Gyokeres’ hands-over-his-face goal celebration. That may have wound Sporting up as they came out after the interval meaning business, and they pulled one back after Raya tipped Hidemasa Morita’s shot behind, with Goncalo Inacio netting at the near post from the corner. Former Tottenham winger Marcus Edwards fired over, as did Gyokeres, with Arsenal temporarily on the back foot. But when Martin Odegaard’s darting run into the area was halted by Ousmane Diomande’s foul, Saka tucked away the penalty. Substitute Trossard added the fifth with eight minutes remaining, heading in the rebound after Mikel Merino’s shot was saved, and Gyokeres’ miserable night was summed up when his late shot crashed back off the post.The hottest topic in energy circles right now – apart from dealing with the – is battery storage, the plunging price of battery cells and its implications for a future renewable-dominated grid supported by flexible capacity. The CSIRO and the Australian Energy Market Operator earlier this month noted in their draft GenCost report that in terms of price – down 20 per cent from where it was just 12 months ago. An annual assessment from Bloomberg NEF supported that assessment. Since then, an auction in China – the country’s biggest for energy storage – suggests that the price decline in battery cells, thanks to intense competition, technology and efficiency improvements and boosted manufacturing capacity, may be even more dramatic than that. According to reports out of China, the Power Construction Corporation of China (PowerChina) has attracted 76 bidders for its unprecedented tender of 16 GWh. The bids were opened on December 4, and according to PV Mag, has attracted prices ranging from $US60.5/kWh to $US82/kWh, with an averaging of $US66.3/kWh. It said 60 of the bids were below $68.4/kWh. The tender is for the supply of energy storage systems – specifically lithium iron phosphate (LFP) battery cells – that will be built in 2025-2026. The winners will be announced after another series of round that will clarify supply chains, equipment quality and delivery ability. The price reportedly includes a comprehensive range of services beyond the delivery of storage equipment, including system design, installation guidance, commissioning, 20-year maintenance, and integrated safety features. “(These are) mind-blowing numbers,” said Marek Rubik, the founder of US-based battery technology company Fluence, and now a director of Saudi green energy project Neom. “(This is) system pricing, not cells,” he wrote on LinkedIn. This, of course, has great significance for the transition to renewables in the main grid, and potentially the shift to EVs in the transport sector. Battery project prices in – albeit still at a cost of around $A300/kWh, which would include local costs such as planning, labour and balance of plant. Just last week, new data from BNEF confirmed the CSIRO and AEMO estimates that battery storage prices had fallen 20 per cent in the last year. Its data showed that the price of lithium-ion battery packs had seen their largest annual drop since 2017, dropping to $US115 per kilowatt-hour – down from $US806 in 2013 and $US144 in 2023. BNEF cited a number of factors in the ongoing decline, including cell manufacturing overcapacity, economies of scale, low metal and component prices, adoption of lower-cost lithium-iron-phosphate (LFP) batteries, as well as a slowdown in electric vehicle sales growth. Overcapacity, in particular, is high, with 3.1TWh of fully commissioned battery-cell manufacturing capacity around the globe, put in place ahead of what battery manufacturers expected to be increased demand for EV batteries. BNEF says the EV market remains the largest source of battery demand – although it has slowed this year – while the stationary storage markets have “taken off”, according to BNEF, with strong competition across both cell and system providers, especially in China. “The price drop for battery cells this year was greater compared with that seen in battery metal prices, indicating that margins for battery manufacturers are being squeezed,” , the head of BNEF’s battery technology team and lead author of the report. “Smaller manufacturers face particular pressure to lower cell prices to fight for market share.” BNEF noted that the $US115/kWh price point is a global average. It cited then that battery pack prices were lowest in China, coming in at around $US94/kWh. The latest tender results suggest another 20 per cent reduction is already in train. However, BNEF noted it is unclear what the future will bring. While low raw material prices have also helped push down costs, these prices could rise in the next few years, with the threat of increasing geopolitical tensions, tariffs on battery metals, and low prices stalling new mining and refining projects. “One thing we’re watching is how new tariffs on finished battery products may lead to distortionary pricing dynamics and slow end-product demand,” said Yayoi Sekine, head of energy storage at BNEF. “Regardless, higher adoption of LFP chemistries, continued market competition, improvements in technology, material processing and manufacturing will exert downward pressure on battery prices.” The China tender is part of PowerChina’s broader equipment procurement plan that were announced on November 13. These includes 51 GW of solar modules, 51 GW of inverters, 25 GW of wind turbines, and 15,240 prefabricated 35kV substations.PSV stage dramatic comeback with three late goals to beat Shakhtar

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WHIPPANY, N.J. , Nov. 27, 2024 /PRNewswire/ -- Suburban Propane Partners, L.P. (NYSE:SPH), today announced that it has filed its Annual Report on Form 10-K for its fiscal year ended September 28, 2024 with the Securities and Exchange Commission ("SEC"). A link to the fiscal 2024 Annual Report on Form 10-K, as filed with the SEC, is available on the Partnership's website at www.suburbanpropane.com . Upon written request, the Partnership will provide to any unitholder or noteholder, without charge, a hard copy of its Annual Report on Form 10-K for the year ended September 28, 2024 . Requests should be directed to: Suburban Propane Partners, L.P., Investor Relations, P.O. Box 206, Whippany, New Jersey 07981-0206. About Suburban Propane Partners, L.P. Suburban Propane Partners, L.P. ("Suburban Propane") is a publicly traded master limited partnership listed on the New York Stock Exchange. Headquartered in Whippany, New Jersey , Suburban Propane has been in the customer service business since 1928 and is a nationwide distributor of propane, renewable propane, renewable natural gas ("RNG"), fuel oil and related products and services, as well as a marketer of natural gas and electricity and producer of and investor in low carbon fuel alternatives, servicing the energy needs of approximately 1 million residential, commercial, governmental, industrial and agricultural customers through approximately 700 locations across 42 states. Suburban Propane is supported by three core pillars: (1) Suburban Commitment – showcasing Suburban Propane's over 95-year legacy, and ongoing commitment to the highest standards for dependability, flexibility, and reliability that underscores Suburban Propane's commitment to excellence in customer service; (2) SuburbanCares – highlighting continued dedication to giving back to local communities across Suburban Propane's national footprint; and (3) Go Green with Suburban Propane – promoting the clean burning and versatile nature of propane and renewable propane as a bridge to a green energy future and investing in the next generation of innovative, renewable energy alternatives. For additional information on Suburban Propane, please visit www.suburbanpropane.com . View original content to download multimedia: https://www.prnewswire.com/news-releases/suburban-propane-partners-lp-annual-report-available-online-302317708.html SOURCE Suburban Propane Partners, L.P.

CARBONDALE, Ill. (AP) — Southern Illinois quarterback Michael Lindauer's coming-out party also was a dazzling farewell. The senior graduate assistant, pressed into duty as a player again when injuries left the Salukis in need of a quarterback, made his first career start — on Senior Day, no less — and threw for a school-record seven touchdowns in a 62-0 victory over Murray State on Saturday. Javascript is required for you to be able to read premium content. Please enable it in your browser settings.